个人简介:
谢文林,男,1967年生,博士,教授,硕士生导师,毕业于中山大学。主要从事有机合成、生物有机化学、多肽药物等科研和教学工作。承担《有机化学》和《高等有机化学》等课程的教学工作。近年来主持国家自然科学基金面上项目1项、湖南省自然科学基金等省部级项目6项、多肽药物研发横向课题2项。获省部级教学成果二等奖1项,指导研究生获湖南省第八届研究生创新论坛优秀论文一等奖1项。在《Eur. J. Med. Chem.》、《Chem. Biol. Drug Des.》、《Bioorg. Med. Chem. Lett.》、《J. pept. Sci.》、《Spectrochimica Acta Part A》、《Res. Chem. Intermediat》、《化学学报》和《有机化学》等国内外重要刊物上共发表学术论文45篇,SCI收录20篇。授权国家发明专利3项,出版教材1部。
联系方式:
Email: xwl2000zsu@163.com
主持的科研或教研项目:
以G-四链体为靶的Isatin衍生物及其金属配合物的合成和抗癌作用(No. 21571058),国家自然科学基金, 70.0万元, 2016,01-2019,12
发表的主要论文:
1. Wenlin Xie*, Huilin Zhang, Jingjing He, Jingai Zhang, Qiuyan Yu, Chunxiang Luo, Shangru Li,Synthesis and Biological Evaluation of novel hydroxybenzaldehyde-based analogues as inhibitors of mushroom tyrosinase, Bioorganic & Medicinal Chemistry Letters, 2017,27(3): 530-532
2. Wenlin Xie *, Jingai Zhang, Xiaojing Ma, Wenqian Yang, Ying Zhou, Xufu Tang, Yan Zou,
Hui Li, Jingjing He, Shimin Xie, Yunhui Zhao, Fengping Liu,Evaluation of Kojic Acid Derivatives Containing 1,2,4-triazole as Potent Tyrosinase Inhibitors, Chemical Biology & Drug Design (Chem. Biol. Drug. Des.), 2015, 86(5): 1087–1092
3. Wenlin Xie*, Shimin Xie, Ying Zhou, Xufu Tang, Jian Liu, Wenqian Yang, Minghua Qiu, Design and synthesis of novel 5,6-disubstituted pyridine-2,3- dione-3-thiosemicarbazone derivatives as potential anticancer agents, European Journal of Medicinal Chemistry, 2014, 81, 22-27
4. Xianyong Yu*, Zhixi Liao, Qing Yao, Heting Liu, Wenlin Xie*, Spectroscopic studies on the interaction of phacolysin and bovine serum albumin, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 127, 231–236
5. Wen Lin Xie, Chuang Ping Xiao, Ling Xie, Ying Zhou, Xue Feng Li, Xu Fu Tang, Chun Tao Yuan, Ming Hua Qiu, Synthesis of 4,5,6-trisubstituted 2,3-pyridinediones via Mannich reaction and oxidation–Michael addition of 3-hydroxy-2(1H)-pyridinones, Research on Chemical Intermediates, 2012, 38(7): 1699-1705
6. Wenlin Xie,* Ying Zhou, Chuangping Xiao, Ling Xie, Xufu Tang and Renyuan Liu, A facile and efficient iodination of 5,6-di(arylamino)pyridine-2,3-diones, Journal of Chemical Research, 2012, 36(2): 103-104
7. Wenlin Xie∗, Jian Liu, Minghua Qiu, Jiancheng Yuan, and Anlong Xu, Design, synthesis and biological activity of cell-penetrating peptide-modified octreotide analogs. Journal of peptide scicence, 2010, 16(2): 105-109
出版教材或专著:
谢文林等主编. 有机化学实验,湘潭大学出版社,2012
授权发明专利:
1. 谢文林,唐绪福,杨文前,腾珍珍, 一种5-取代-4-[5-羟基-4-吡喃酮-2-基-亚甲氨基]-3-巯基-1,2,4-**类化合物及其用途,专利号:ZL201310235619.6.
2. 谢文林,唐绪福, 杨文前, 5-取代-3-[5-羟基-4-吡喃酮-2-基-甲硫基]-4-氨基-1,2,4-**类化合物及其用途, 专利号:ZL201310198771.1.
3. 谢文林,张慧霖,余秋艳,吴乙强,梅期宏,骆春香,一种含螺吲哚-2-酮衍生物及其制备方法和作为抗癌药物的应用,专利号:ZL201610309985.5